Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Six2  sine oculis-related homeobox 2
Results	Reference
1	J:315767 Ahn SY, Kim Y, Kim ST, Swat W, Miner JH, Scaffolding proteins DLG1 and CASK cooperate to maintain the nephron progenitor population during kidney development. J Am Soc Nephrol. 2013 Jun;24(7):1127-38
1	J:226938 Bagherie-Lachidan M, Reginensi A, Pan Q, Zaveri HP, Scott DA, Blencowe BJ, Helmbacher F, McNeill H, Stromal Fat4 acts non-autonomously with Dchs1/2 to restrict the nephron progenitor pool. Development. 2015 Aug 1;142(15):2564-73
1	J:229163 Blake J, Hu D, Cain JE, Rosenblum ND, Urogenital development in Pallister-Hall syndrome is disrupted in a cell-lineage-specific manner by constitutive expression of GLI3 repressor. Hum Mol Genet. 2016 Feb 1;25(3):437-47
1	J:214091 Brunskill EW, Park JS, Chung E, Chen F, Magella B, Potter SS, Single cell dissection of early kidney development: multilineage priming. Development. 2014 Aug;141(15):3093-101
1	J:276713 Cargill K, Hemker SL, Clugston A, Murali A, Mukherjee E, Liu J, Bushnell D, Bodnar AJ, Saifudeen Z, Ho J, Bates CM, Kostka D, Goetzman ES, Sims-Lucas S, Von Hippel-Lindau Acts as a Metabolic Switch Controlling Nephron Progenitor Differentiation. J Am Soc Nephrol. 2019 Jul;30(7):1192-1205
1	J:274119 Combes AN, Wilson S, Phipson B, Binnie BB, Ju A, Lawlor KT, Cebrian C, Walton SL, Smyth IM, Moritz KM, Kopan R, Oshlack A, Little MH, Haploinsufficiency for the Six2 gene increases nephron progenitor proliferation promoting branching and nephron number. Kidney Int. 2018 Mar;93(3):589-598
1*	J:144178 Couillard M, Trudel M, C-myc as a modulator of renal stem/progenitor cell population. Dev Dyn. 2009 Feb;238(2):405-14
1	J:201586 Das A, Tanigawa S, Karner CM, Xin M, Lum L, Chen C, Olson EN, Perantoni AO, Carroll TJ, Stromal-epithelial crosstalk regulates kidney progenitor cell differentiation. Nat Cell Biol. 2013 Sep;15(9):1035-44
1	J:221164 Di Giovanni V, Walker KA, Bushnell D, Schaefer C, Sims-Lucas S, Puri P, Bates CM, Fibroblast growth factor receptor-Frs2alpha signaling is critical for nephron progenitors. Dev Biol. 2015 Apr 1;400(1):82-93
1	J:295217 Drake KA, Chaney CP, Das A, Roy P, Kwartler CS, Rakheja D, Carroll TJ, Stromal beta-catenin activation impacts nephron progenitor differentiation in the developing kidney and may contribute to Wilms tumor. Development. 2020 Jul 31;147(21):dev189597
1	J:234059 Elias BC, Das A, Parekh DV, Mernaugh G, Adams R, Yang Z, Brakebusch C, Pozzi A, Marciano DK, Carroll TJ, Zent R, Cdc42 regulates epithelial cell polarity and cytoskeletal function during kidney tubule development. J Cell Sci. 2015 Dec 1;128(23):4293-305
1	J:206309 Fetting JL, Guay JA, Karolak MJ, Iozzo RV, Adams DC, Maridas DE, Brown AC, Oxburgh L, FOXD1 promotes nephron progenitor differentiation by repressing decorin in the embryonic kidney. Development. 2014 Jan;141(1):17-27
1	J:333283 Guan N, Kobayashi H, Ishii K, Davidoff O, Sha F, Ikizler TA, Hao CM, Chandel NS, Haase VH, Disruption of mitochondrial complex III in cap mesenchyme but not in ureteric progenitors results in defective nephrogenesis associated with amino acid deficiency. Kidney Int. 2022 Jul;102(1):108-120
1*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
1*	J:173795 Hilliard S, Aboudehen K, Yao X, El-Dahr SS, Tight regulation of p53 activity by Mdm2 is required for ureteric bud growth and branching. Dev Biol. 2011 May 15;353(2):354-66
1	J:343095 Honeycutt SE, N'Guetta PY, Hardesty DM, Xiong Y, Cooper SL, Stevenson MJ, O'Brien LL, Netrin 1 directs vascular patterning and maturity in the developing kidney. Development. 2023 Nov 15;150(22)
1	J:239651 Hurtado R, Zewdu R, Mtui J, Liang C, Aho R, Kurylo C, Selleri L, Herzlinger D, Pbx1-dependent control of VMC differentiation kinetics underlies gross renal vascular patterning. Development. 2015 Aug 01;142(15):2653-64
1	J:333402 Ihermann-Hella A, Hirashima T, Kupari J, Kurtzeborn K, Li H, Kwon HN, Cebrian C, Soofi A, Dapkunas A, Miinalainen I, Dressler GR, Matsuda M, Kuure S, Dynamic MAPK/ERK Activity Sustains Nephron Progenitors through Niche Regulation and Primes Precursors for Differentiation. Stem Cell Reports. 2018 Oct 9;11(4):912-928
1	J:267799 Kanda S, Tanigawa S, Ohmori T, Taguchi A, Kudo K, Suzuki Y, Sato Y, Hino S, Sander M, Perantoni AO, Sugano S, Nakao M, Nishinakamura R, Sall1 maintains nephron progenitors and nascent nephrons by acting as both an activator and a repressor. J Am Soc Nephrol. 2014 Nov;25(11):2584-95
1	J:220461 Kann M, Bae E, Lenz MO, Li L, Trannguyen B, Schumacher VA, Taglienti ME, Bordeianou L, Hartwig S, Rinschen MM, Schermer B, Benzing T, Fan CM, Kreidberg JA, WT1 targets Gas1 to maintain nephron progenitor cells by modulating FGF signals. Development. 2015 Apr 1;142(7):1254-66
1	J:239220 Kobayashi A, Mugford JW, Krautzberger AM, Naiman N, Liao J, McMahon AP, Identification of a multipotent self-renewing stromal progenitor population during mammalian kidney organogenesis. Stem Cell Reports. 2014 Oct 14;3(4):650-62
1	J:320427 Kobayashi H, Liu J, Urrutia AA, Burmakin M, Ishii K, Rajan M, Davidoff O, Saifudeen Z, Haase VH, Hypoxia-inducible factor prolyl-4-hydroxylation in FOXD1 lineage cells is essential for normal kidney development. Kidney Int. 2017 Dec;92(6):1370-1383
1*	J:296648 Lindstrom NO, Guo J, Kim AD, Tran T, Guo Q, De Sena Brandine G, Ransick A, Parvez RK, Thornton ME, Baskin L, Grubbs B, McMahon JA, Smith AD, McMahon AP, Conserved and Divergent Features of Mesenchymal Progenitor Cell Types within the Cortical Nephrogenic Niche of the Human and Mouse Kidney. J Am Soc Nephrol. 2018 Mar;29(3):806-824
1*	J:273779 Lindstrom NO, McMahon JA, Guo J, Tran T, Guo Q, Rutledge E, Parvez RK, Saribekyan G, Schuler RE, Liao C, Kim AD, Abdelhalim A, Ruffins SW, Thornton ME, Baskin L, Grubbs B, Kesselman C, McMahon AP, Conserved and Divergent Features of Human and Mouse Kidney Organogenesis. J Am Soc Nephrol. 2018 Mar;29(3):785-805
1*	J:296649 Lindstrom NO, Tran T, Guo J, Rutledge E, Parvez RK, Thornton ME, Grubbs B, McMahon JA, McMahon AP, Conserved and Divergent Molecular and Anatomic Features of Human and Mouse Nephron Patterning. J Am Soc Nephrol. 2018 Mar;29(3):825-840
1	J:298947 Liu H, Hilliard S, Kelly E, Chen CH, Saifudeen Z, El-Dahr SS, The polycomb proteins EZH1 and EZH2 co-regulate chromatin accessibility and nephron progenitor cell lifespan in mice. J Biol Chem. 2020 Aug 14;295(33):11542-11558
1	J:343073 Luo PM, Gu X, Chaney C, Carroll T, Cleaver O, Stromal netrin 1 coordinates renal arteriogenesis and mural cell differentiation. Development. 2023 Nov 15;150(22)
1	J:239657 Mao Y, Francis-West P, Irvine KD, Fat4/Dchs1 signaling between stromal and cap mesenchyme cells influences nephrogenesis and ureteric bud branching. Development. 2015 Aug 01;142(15):2574-85
1	J:143306 Mugford JW, Sipila P, McMahon JA, McMahon AP, Osr1 expression demarcates a multi-potent population of intermediate mesoderm that undergoes progressive restriction to an Osr1-dependent nephron progenitor compartment within the mammalian kidney. Dev Biol. 2008 Dec 1;324(1):88-98
1	J:152419 Mugford JW, Yu J, Kobayashi A, McMahon AP, High-resolution gene expression analysis of the developing mouse kidney defines novel cellular compartments within the nephron progenitor population. Dev Biol. 2009 Sep 15;333(2):312-23
1*	J:241850 Naiman N, Fujioka K, Fujino M, Valerius MT, Potter SS, McMahon AP, Kobayashi A, Repression of Interstitial Identity in Nephron Progenitor Cells by Pax2 Establishes the Nephron-Interstitium Boundary during Kidney Development. Dev Cell. 2017 May 22;41(4):349-365.e3
1	J:309403 Nakagawa N, Xin C, Roach AM, Naiman N, Shankland SJ, Ligresti G, Ren S, Szak S, Gomez IG, Duffield JS, Dicer1 activity in the stromal compartment regulates nephron differentiation and vascular patterning during mammalian kidney organogenesis. Kidney Int. 2015 Jun;87(6):1125-40
1	J:267385 O'Brien LL, Combes AN, Short KM, Lindstrom NO, Whitney PH, Cullen-McEwen LA, Ju A, Abdelhalim A, Michos O, Bertram JF, Smyth IM, Little MH, McMahon AP, Wnt11 directs nephron progenitor polarity and motile behavior ultimately determining nephron endowment. Elife. 2018 Dec 5;7:e40392
1	J:283584 O'Brien LL, Guo Q, Lee Y, Tran T, Benazet JD, Whitney PH, Valouev A, McMahon AP, Differential regulation of mouse and human nephron progenitors by the Six family of transcriptional regulators. Development. 2016 Feb 15;143(4):595-608
1	J:316149 Okello DO, Iyyanar PPR, Kulyk WM, Smith TM, Lozanoff S, Ji S, Nazarali AJ, Six2 Plays an Intrinsic Role in Regulating Proliferation of Mesenchymal Cells in the Developing Palate. Front Physiol. 2017;8:955
1	J:248185 Pan X, Karner CM, Carroll TJ, Myc cooperates with beta-catenin to drive gene expression in nephron progenitor cells. Development. 2017 Nov 15;144(22):4173-4182
1	J:188777 Park JS, Ma W, O'Brien LL, Chung E, Guo JJ, Cheng JG, Valerius MT, McMahon JA, Wong WH, McMahon AP, Six2 and Wnt regulate self-renewal and commitment of nephron progenitors through shared gene regulatory networks. Dev Cell. 2012 Sep 11;23(3):637-51
1	J:239799 Raines AM, Magella B, Adam M, Potter SS, Key pathways regulated by HoxA9,10,11/HoxD9,10,11 during limb development. BMC Dev Biol. 2015 Jul 19;15:28
1	J:264384 Ramalingam H, Fessler AR, Das A, Valerius MT, Basta J, Robbins L, Brown AC, Oxburgh L, McMahon AP, Rauchman M, Carroll TJ, Disparate levels of beta-catenin activity determine nephron progenitor cell fate. Dev Biol. 2018 Aug 1;440(1):13-21
1	J:195266 Reginensi A, Scott RP, Gregorieff A, Bagherie-Lachidan M, Chung C, Lim DS, Pawson T, Wrana J, McNeill H, Yap- and Cdc42-Dependent Nephrogenesis and Morphogenesis during Mouse Kidney Development. PLoS Genet. 2013 Mar;9(3):e1003380
1	J:264120 Rowan CJ, Li W, Martirosyan H, Erwood S, Hu D, Kim YK, Sheybani-Deloui S, Mulder J, Blake J, Chen L, Rosenblum ND, Hedgehog-GLI signaling in Foxd1-positive stromal cells promotes murine nephrogenesis via TGFbeta signaling. Development. 2018 Jul 9;145(13):dev159947
1*	J:178471 Rumballe BA, Georgas KM, Combes AN, Ju AL, Gilbert T, Little MH, Nephron formation adopts a novel spatial topology at cessation of nephrogenesis. Dev Biol. 2011 Dec 1;360(1):110-22
1	J:208128 Sarin S, Boivin F, Li A, Lim J, Svajger B, Rosenblum ND, Bridgewater D, beta-Catenin Overexpression in the Metanephric Mesenchyme Leads to Renal Dysplasia Genesis via Cell-Autonomous and Non-Cell-Autonomous Mechanisms. Am J Pathol. 2014 May;184(5):1395-410
1*	J:285711 Sweat YY, Sweat M, Mansaray M, Cao H, Eliason S, Adeyemo WL, Gowans LJJ, Eshete MA, Anand D, Chalkley C, Saadi I, Lachke SA, Butali A, Amendt BA, Six2 regulates Pax9 expression, palatogenesis and craniofacial bone formation. Dev Biol. 2020 Feb 15;458(2):246-256
1	J:211179 Urbach A, Yermalovich A, Zhang J, Spina CS, Zhu H, Perez-Atayde AR, Shukrun R, Charlton J, Sebire N, Mifsud W, Dekel B, Pritchard-Jones K, Daley GQ, Lin28 sustains early renal progenitors and induces Wilms tumor. Genes Dev. 2014 May 1;28(9):971-82
1*	J:296647 Wanner N, Vornweg J, Combes A, Wilson S, Plappert J, Rafflenbeul G, Puelles VG, Rahman RU, Liwinski T, Lindner S, Grahammer F, Kretz O, Wlodek ME, Romano T, Moritz KM, Boerries M, Busch H, Bonn S, Little MH, Bechtel-Walz W, Huber TB, DNA Methyltransferase 1 Controls Nephron Progenitor Cell Renewal and Differentiation. J Am Soc Nephrol. 2019 Jan;30(1):63-78